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Diffuse axonal injuries are treated very similarly to other head injuries. In most cases, watchful waiting is the main course of treatment. Most people with diffuse axonal injuries are admitted to the hospital for observation and care. Pain associated with the head injury and other injuries sustained can be treated with painkillers like acetaminophen. 

but In some cases, brain swelling may cause extreme pressure on the skull; if this is the case, surgery may be recommended to relieve pressure.